Can you inherit endometriosis?
Doctors already suspected that endometriosis runs in families. Now, there’s convincing new evidence to support the theory of a genetic link.
MUST READ: What is Endometriosis?
Endometriosis could be a condition in which uterine tissue grows outside the female internal reproductive organ, attaching to numerous organs and ligaments in the abdominal cavity. This tissue acts like normal uterine tissue, growing and disintegrating with every menstrual cycle. this can cause pain, bleeding, and in some cases, infertility.
In Iceland, each citizen’s family and health records are held on in a very comprehensive database, permitting large, highly-detailed population studies. For this investigation, researchers from decode genetics and Landspitalinn University Hospital, both in Reykjavík, looked at records for all 750 girls diagnosed with endometriosis between 1981 and 1993.
MUST READ: 10 Major causes of Endometriosis
Their findings seem in the most recent issue of the population-wide medical journal Human reproduction.
They found girls with endometriosis were considerably more likely to be associated with one another than were healthy women in a control group. Not only did a lady have over five times the conventional risk of developing endometriosis if her sister had it, but she was also 500th more probably than normal to develop endometriosis if a cousin had it. This clinched the fact that genes were involved. It also revealed that fathers might pass the faulty genes on to their daughters.
Now the challenge is figuring out precisely that gene or genes are accountable.
“By using our populationwide genealogical resources and applied mathematics models for measuring kinship, we’ve got for the first time demonstrated the existence of a hereditary component to endometriosis that may be derived on the far side first-generation relatives,” says study co-author Kari Stefansson, MD, president and chief executive officer of decode.
These findings have begun “a genomewide scan to spot key genes that contribute to the disease,” says Stefansson during a news release. By pinpointing the actual genes concerned, scientists will better focus prevention and treatment efforts.
The team is already trying to make a DNA-based screening test. “Such a test would assist in diagnosing the disease and in distinctive ladies at particular risk of endometriosis, without the requirement for invasive procedures,” he says.